There are only three video podcasts that I watch each week. One is a board game podcast called Board Games with Scott. The other two are pop-tech based; one is Diggnation and the other is The Totally Rad Show.
Now I think the common feeling on the blagoblag is that Diggnation is one of the best podcasts out there, and I agree that it is good and it does make me laugh alot. But recently I have really come to like The Totally Rad Show. It isn't as funny, but I really like the way the hosts interact with each other (like really good friends) and I respect their opinions.
So I am going to just come out and say it: The Totally Rad Show is better than Diggnation. (If this was posted on some geek forum a flam war would now ensue.)
I suggest looking into all three podcasts, although Diggnation and TRS do swear some, so be forewarned. (And at times Board Games with Scott is just weird.)